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Lifestyle interventions that reshape ROS tone (mechanism-anchored) Lifestyle levers can reset ROS tone in ways drugs often can’t: exercise training induces mitochondrial biogenesis and mitophagy, improves endothelial NO bioavailability and upregulates endogenous antioxidant systems so that the pulsatile ROS generated during bouts acts as a mitohormetic signal rather than a damaging load (Guan et al

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